Drug interactions
Esketamine + Fenfluramine
Severity: Moderate
Esketamine and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine releases serotonin, and combining it with other agents that influence serotonergic activity may increase the risk of serotonin syndrome. Esketamine has limited direct serotonergic activity, so the risk is mainly theoretical.
What this interaction means in plain words
Esketamine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; fenfluramine increases synaptic serotonin.
What to do
Monitor for agitation, tremor, hyperreflexia, sweating and hyperthermia after esketamine doses. Stop the interacting drugs and give supportive care if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Esketamine with Fenfluramine?
MediHelp rates the interaction as moderate. Esketamine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine releases serotonin, and combining it with other agents that influence serotonergic activity may increase the risk of serotonin syndrome. Esketamine has limited direct serotonergic activity, so the risk is mainly theoretical.
How serious is the interaction between Esketamine and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperreflexia, sweating and hyperthermia after esketamine doses. Stop the interacting drugs and give supportive care if serotonin syndrome is suspected.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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