Drug interactions
Esketamine + Fexofenadine
Severity: Minor
Esketamine and Fexofenadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexofenadine is a non-sedating antihistamine, so additive sedation with esketamine is unlikely at usual doses.
What this interaction means in plain words
Esketamine and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esketamine belongs to Central Nervous System; Fexofenadine belongs to Respiratory.
Why it happens
Minimal central penetration of fexofenadine; any additive CNS effect is slight.
What to do
No change is usually needed. Observe patients as routine for sedation after esketamine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esketamine
Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Frequently asked questions
Can I take Esketamine with Fexofenadine?
MediHelp rates the interaction as minor. Esketamine and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fexofenadine is a non-sedating antihistamine, so additive sedation with esketamine is unlikely at usual doses.
How serious is the interaction between Esketamine and Fexofenadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is usually needed. Observe patients as routine for sedation after esketamine.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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