Drug interactions
Esketamine + Methamphetamine
Severity: Major
Esketamine and Methamphetamine: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise blood pressure and heart rate. Combined use can cause a larger hypertensive response, which is especially important after esketamine dosing, and may provoke cardiovascular events in susceptible patients.
What this interaction means in plain words
Esketamine and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Esketamine belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Additive sympathomimetic pressor effects of esketamine and methamphetamine.
What to do
Check blood pressure before dosing and again after esketamine administration. Avoid use in patients with uncontrolled hypertension and seek an alternative to the stimulant if pressure stays elevated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Esketamine
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Esketamine with Methamphetamine?
MediHelp rates the interaction as major. Esketamine and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs raise blood pressure and heart rate. Combined use can cause a larger hypertensive response, which is especially important after esketamine dosing, and may provoke cardiovascular events in susceptible patients.
How serious is the interaction between Esketamine and Methamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure before dosing and again after esketamine administration. Avoid use in patients with uncontrolled hypertension and seek an alternative to the stimulant if pressure stays elevated.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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