Drug interactions
Esketamine + Modafinil
Severity: Moderate
Esketamine and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil is a wakefulness-promoting agent that can modestly raise blood pressure and heart rate. Esketamine produces transient pressor effects, so the combination may produce a larger rise in blood pressure.
What this interaction means in plain words
Esketamine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Additive cardiovascular stimulation from esketamine and modafinil.
What to do
Record blood pressure before and after each esketamine session. Defer dosing if baseline pressure is high and review the need for modafinil if elevations persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Modafinil
Frequently asked questions
Can I take Esketamine with Modafinil?
MediHelp rates the interaction as moderate. Esketamine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil is a wakefulness-promoting agent that can modestly raise blood pressure and heart rate. Esketamine produces transient pressor effects, so the combination may produce a larger rise in blood pressure.
How serious is the interaction between Esketamine and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Record blood pressure before and after each esketamine session. Defer dosing if baseline pressure is high and review the need for modafinil if elevations persist.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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