Drug interactions
Esketamine + Risperidone
Severity: Moderate
Esketamine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause sedation and orthostatic hypotension, which may add to the drowsiness and dissociation of esketamine. The effect is usually manageable.
What this interaction means in plain words
Esketamine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and alpha-1 adrenergic blockade combined with NMDA antagonism.
What to do
Monitor sedation and blood pressure during the post-dose observation period. Adjust antipsychotic dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Esketamine with Risperidone?
MediHelp rates the interaction as moderate. Esketamine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause sedation and orthostatic hypotension, which may add to the drowsiness and dissociation of esketamine. The effect is usually manageable.
How serious is the interaction between Esketamine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during the post-dose observation period. Adjust antipsychotic dose if excessive sedation occurs.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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