Drug interactions
Esketamine + Stiripentol
Severity: Moderate
Esketamine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol causes somnolence and is typically taken with clobazam and valproate, so additive sedation with esketamine is likely. Stiripentol inhibits several CYP enzymes, but a pharmacokinetic effect on esketamine has not been well characterized.
What this interaction means in plain words
Esketamine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression; possible CYP inhibition by stiripentol affecting esketamine metabolism is not well established.
What to do
Monitor sedation and respiratory status after esketamine dosing and counsel on avoiding driving. Review the overall sedative load of the antiseizure regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Stiripentol
Frequently asked questions
Can I take Esketamine with Stiripentol?
MediHelp rates the interaction as moderate. Esketamine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol causes somnolence and is typically taken with clobazam and valproate, so additive sedation with esketamine is likely. Stiripentol inhibits several CYP enzymes, but a pharmacokinetic effect on esketamine has not been well characterized.
How serious is the interaction between Esketamine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status after esketamine dosing and counsel on avoiding driving. Review the overall sedative load of the antiseizure regimen.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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