Drug interactions
Esketamine + Trimipramine
Severity: Moderate
Esketamine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a sedating tricyclic antidepressant and can add to the drowsiness and blood pressure effects of esketamine. Anticholinergic effects may also worsen confusion.
What this interaction means in plain words
Esketamine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression from antihistaminic and anticholinergic effects plus NMDA antagonism.
What to do
Monitor sedation, mental status and blood pressure after dosing and adjust the tricyclic dose if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Esketamine with Trimipramine?
MediHelp rates the interaction as moderate. Esketamine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a sedating tricyclic antidepressant and can add to the drowsiness and blood pressure effects of esketamine. Anticholinergic effects may also worsen confusion.
How serious is the interaction between Esketamine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, mental status and blood pressure after dosing and adjust the tricyclic dose if oversedation occurs.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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