Drug interactions
Esketamine + Vigabatrin
Severity: Moderate
Esketamine and Vigabatrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vigabatrin can cause somnolence and fatigue, which may add to esketamine sedation and dizziness.
What this interaction means in plain words
Esketamine and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Vigabatrin belongs to Central Nervous System.
Why it happens
Additive CNS depression via pharmacodynamic synergism.
What to do
Monitor sedation after each esketamine session and advise against driving or hazardous tasks until the next day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Vigabatrin
- Amisulpride + Vigabatrin Moderate
- Asenapine transdermal + Vigabatrin Moderate
- Asenapine + Vigabatrin Moderate
- Avapritinib + Vigabatrin Moderate
- Benzhydrocodone / acetaminophen + Vigabatrin Moderate
- Brexanolone + Vigabatrin Moderate
Frequently asked questions
Can I take Esketamine with Vigabatrin?
MediHelp rates the interaction as moderate. Esketamine and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vigabatrin can cause somnolence and fatigue, which may add to esketamine sedation and dizziness.
How serious is the interaction between Esketamine and Vigabatrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation after each esketamine session and advise against driving or hazardous tasks until the next day.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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