Drug interactions
Esketamine + Zonisamide
Severity: Moderate
Esketamine and Zonisamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zonisamide can cause somnolence and cognitive slowing, which may add to esketamine effects on alertness.
What this interaction means in plain words
Esketamine and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Zonisamide belongs to Central Nervous System.
Why it happens
Additive CNS depression via pharmacodynamic synergism.
What to do
Monitor sedation after esketamine sessions and counsel patients against driving until the next day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Esketamine with Zonisamide?
MediHelp rates the interaction as moderate. Esketamine and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zonisamide can cause somnolence and cognitive slowing, which may add to esketamine effects on alertness.
How serious is the interaction between Esketamine and Zonisamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation after esketamine sessions and counsel patients against driving until the next day.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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