Drug interactions
Esketamine intranasal + Fexofenadine
Severity: Minor
Esketamine intranasal and Fexofenadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation, dissociation and dizziness. Fexofenadine rarely causes sedation, so a clinically relevant additive effect is unlikely, but it cannot be excluded.
What this interaction means in plain words
Esketamine intranasal and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Potential additive CNS depression; fexofenadine has minimal central effects.
What to do
No change is required; follow standard post-dose observation for esketamine and advise against driving until the next day after a restful sleep.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Frequently asked questions
Can I take Esketamine intranasal with Fexofenadine?
MediHelp rates the interaction as minor. Esketamine intranasal and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Esketamine causes sedation, dissociation and dizziness. Fexofenadine rarely causes sedation, so a clinically relevant additive effect is unlikely, but it cannot be excluded.
How serious is the interaction between Esketamine intranasal and Fexofenadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is required; follow standard post-dose observation for esketamine and advise against driving until the next day after a restful sleep.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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