Drug interactions
Esketamine intranasal + Loratadine
Severity: Minor
Esketamine intranasal and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine commonly causes sedation and dissociation, and loratadine can occasionally cause drowsiness. Combined use may modestly increase sedation after esketamine administration.
What this interaction means in plain words
Esketamine intranasal and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Observe for excess sedation during post-dose monitoring. Advise against driving until the day after esketamine treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Frequently asked questions
Can I take Esketamine intranasal with Loratadine?
MediHelp rates the interaction as minor. Esketamine intranasal and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Esketamine commonly causes sedation and dissociation, and loratadine can occasionally cause drowsiness. Combined use may modestly increase sedation after esketamine administration.
How serious is the interaction between Esketamine intranasal and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe for excess sedation during post-dose monitoring. Advise against driving until the day after esketamine treatment.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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