Drug interactions
Esketamine intranasal + Methamphetamine
Severity: Moderate
Esketamine intranasal and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both esketamine and methamphetamine raise blood pressure and heart rate. Taken together, they can produce larger or more prolonged hypertensive and tachycardic responses than either drug alone, which matters in patients with cardiovascular disease.
What this interaction means in plain words
Esketamine intranasal and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic pharmacodynamic effects on blood pressure and heart rate.
What to do
Measure blood pressure before and after each esketamine session and monitor until it returns to baseline. Avoid or reassess treatment if blood pressure stays elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Esketamine intranasal with Methamphetamine?
MediHelp rates the interaction as moderate. Esketamine intranasal and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both esketamine and methamphetamine raise blood pressure and heart rate. Taken together, they can produce larger or more prolonged hypertensive and tachycardic responses than either drug alone, which matters in patients with cardiovascular disease.
How serious is the interaction between Esketamine intranasal and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure blood pressure before and after each esketamine session and monitor until it returns to baseline. Avoid or reassess treatment if blood pressure stays elevated.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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