Drug interactions
Esketamine intranasal + Modafinil
Severity: Moderate
Esketamine intranasal and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine transiently raises blood pressure and heart rate, and modafinil as a stimulant may add to this. Patients with hypertension or cardiovascular disease are at greater risk.
What this interaction means in plain words
Esketamine intranasal and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic cardiovascular effects.
What to do
Check blood pressure before and after esketamine dosing and for the observation period. Delay or withhold treatment if baseline blood pressure is elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Esketamine intranasal with Modafinil?
MediHelp rates the interaction as moderate. Esketamine intranasal and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine transiently raises blood pressure and heart rate, and modafinil as a stimulant may add to this. Patients with hypertension or cardiovascular disease are at greater risk.
How serious is the interaction between Esketamine intranasal and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure before and after esketamine dosing and for the observation period. Delay or withhold treatment if baseline blood pressure is elevated.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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