Drug interactions
Esketamine intranasal + Pregabalin
Severity: Moderate
Esketamine intranasal and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and pregabalin adds to CNS depression, increasing drowsiness and impaired performance. Respiratory depression is possible with combined CNS depressants.
What this interaction means in plain words
Esketamine intranasal and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through pharmacodynamic synergism.
What to do
Monitor for sedation during and after esketamine dosing per the post-dose observation period. Advise against driving until the next day after a restful sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Frequently asked questions
Can I take Esketamine intranasal with Pregabalin?
MediHelp rates the interaction as moderate. Esketamine intranasal and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation and dissociation, and pregabalin adds to CNS depression, increasing drowsiness and impaired performance. Respiratory depression is possible with combined CNS depressants.
How serious is the interaction between Esketamine intranasal and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation during and after esketamine dosing per the post-dose observation period. Advise against driving until the next day after a restful sleep.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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