Drug interactions
Esketamine intranasal + Tramadol
Severity: Moderate
Esketamine intranasal and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and tramadol adds opioid sedation and respiratory depression. Together they may increase drowsiness and impair alertness after dosing.
What this interaction means in plain words
Esketamine intranasal and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation and respiratory status during and after esketamine sessions in patients taking tramadol. Observe the patient until stable before discharge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Esketamine intranasal with Tramadol?
MediHelp rates the interaction as moderate. Esketamine intranasal and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation and dissociation, and tramadol adds opioid sedation and respiratory depression. Together they may increase drowsiness and impair alertness after dosing.
How serious is the interaction between Esketamine intranasal and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status during and after esketamine sessions in patients taking tramadol. Observe the patient until stable before discharge.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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