Drug interactions
Esketamine intranasal + Trimipramine
Severity: Moderate
Esketamine intranasal and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation and esketamine can raise blood pressure. Combined use may increase drowsiness and impair psychomotor performance.
What this interaction means in plain words
Esketamine intranasal and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression, plus additive blood pressure effects.
What to do
Monitor sedation and blood pressure during and after esketamine dosing, as required by the treatment program. Advise patients not to drive until the next day after a restful sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Esketamine intranasal with Trimipramine?
MediHelp rates the interaction as moderate. Esketamine intranasal and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation and esketamine can raise blood pressure. Combined use may increase drowsiness and impair psychomotor performance.
How serious is the interaction between Esketamine intranasal and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during and after esketamine dosing, as required by the treatment program. Advise patients not to drive until the next day after a restful sleep.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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