Drug interactions
Eslicarbazepine + Imipramine
Severity: Moderate
Eslicarbazepine and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine inhibits CYP2C19, which demethylates imipramine to desipramine, so imipramine exposure may rise modestly. The clinical impact is usually limited, though tricyclic adverse effects may emerge, and eslicarbazepine may also induce other enzymes.
What this interaction means in plain words
Eslicarbazepine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19-mediated imipramine metabolism, with possible mixed enzyme induction effects.
What to do
Monitor clinical response and tricyclic adverse effects after starting or changing eslicarbazepine. Consider measuring imipramine and desipramine levels and adjusting the dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Imipramine?
MediHelp rates the interaction as moderate. Eslicarbazepine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine inhibits CYP2C19, which demethylates imipramine to desipramine, so imipramine exposure may rise modestly. The clinical impact is usually limited, though tricyclic adverse effects may emerge, and eslicarbazepine may also induce other enzymes.
How serious is the interaction between Eslicarbazepine and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and tricyclic adverse effects after starting or changing eslicarbazepine. Consider measuring imipramine and desipramine levels and adjusting the dose.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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