Drug interactions
Eslicarbazepine + Lorlatinib
Severity: Major
Eslicarbazepine and Lorlatinib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine may reduce lorlatinib exposure through CYP3A induction. Strong inducers raise the risk of hepatotoxicity as well as reduced efficacy, so the combination is best avoided.
What this interaction means in plain words
Eslicarbazepine and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eslicarbazepine belongs to Central Nervous System; Lorlatinib belongs to Oncology.
Why it happens
CYP3A4 induction by eslicarbazepine increases lorlatinib metabolism.
What to do
Avoid combined use and choose a non-inducing antiseizure drug. If unavoidable, monitor liver enzymes, bilirubin and tumor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Eslicarbazepine Amarox 200 mg tablets - SmPC sections 4.3/4.5 (class statement: medicinal products that are mainly eliminated by metabolism through CYP3A4; "In vivo eslicarbazepine showed an inducing effect on the metabolism of medicinal products that are mainly eliminated by metabolism through CYP… — electronic medicines compendium (UK SmPC)
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Eslicarbazepine with Lorlatinib?
MediHelp rates the interaction as major. Eslicarbazepine and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eslicarbazepine may reduce lorlatinib exposure through CYP3A induction. Strong inducers raise the risk of hepatotoxicity as well as reduced efficacy, so the combination is best avoided.
How serious is the interaction between Eslicarbazepine and Lorlatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use and choose a non-inducing antiseizure drug. If unavoidable, monitor liver enzymes, bilirubin and tumor response.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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