Drug interactions
Eslicarbazepine + Macitentan
Severity: Moderate
Eslicarbazepine and Macitentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine may lower macitentan and its active metabolite exposure by inducing CYP3A4. This may reduce control of pulmonary arterial hypertension.
What this interaction means in plain words
Eslicarbazepine and Macitentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Macitentan belongs to Cardiovascular.
Why it happens
CYP3A4 induction increases macitentan metabolism.
What to do
Avoid if an alternative anticonvulsant is available; otherwise monitor clinical status and exercise capacity for loss of efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Macitentan
- Amiodarone + Macitentan Major
- Apalutamide + Macitentan Major
- Bosentan + Macitentan Major
- Carbamazepine + Macitentan Major
- Clarithromycin + Macitentan Major
- Efavirenz + Macitentan Major
Frequently asked questions
Can I take Eslicarbazepine with Macitentan?
MediHelp rates the interaction as moderate. Eslicarbazepine and Macitentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine may lower macitentan and its active metabolite exposure by inducing CYP3A4. This may reduce control of pulmonary arterial hypertension.
How serious is the interaction between Eslicarbazepine and Macitentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative anticonvulsant is available; otherwise monitor clinical status and exercise capacity for loss of efficacy.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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