Drug interactions
Eslicarbazepine + Norgestrel
Severity: Major
Eslicarbazepine and Norgestrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine may lower norgestrel concentrations and reduce contraceptive effectiveness, raising the risk of unintended pregnancy.
What this interaction means in plain words
Eslicarbazepine and Norgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eslicarbazepine belongs to Central Nervous System; Norgestrel belongs to Endocrine.
Why it happens
Induction of CYP3A4 increases the metabolism of the progestin.
What to do
Use a non-hormonal or additional barrier method during therapy. Continue backup contraception for about 28 days after stopping eslicarbazepine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Eslicarbazepine with Norgestrel?
MediHelp rates the interaction as major. Eslicarbazepine and Norgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eslicarbazepine may lower norgestrel concentrations and reduce contraceptive effectiveness, raising the risk of unintended pregnancy.
How serious is the interaction between Eslicarbazepine and Norgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal or additional barrier method during therapy. Continue backup contraception for about 28 days after stopping eslicarbazepine.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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