Drug interactions
Eslicarbazepine + Orlistat
Severity: Moderate
Eslicarbazepine and Orlistat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat has been associated with reduced antiepileptic drug levels and breakthrough seizures in case reports, probably due to reduced absorption. Data for eslicarbazepine specifically are lacking and the effect is theoretical.
What this interaction means in plain words
Eslicarbazepine and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Orlistat belongs to Miscellaneous.
Why it happens
Orlistat-induced fat malabsorption may reduce gastrointestinal absorption of antiseizure drugs.
What to do
Monitor seizure frequency when orlistat is started or stopped, and consider avoiding orlistat in patients with poorly controlled epilepsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Orlistat
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
- Cholecalciferol + Orlistat Moderate
Frequently asked questions
Can I take Eslicarbazepine with Orlistat?
MediHelp rates the interaction as moderate. Eslicarbazepine and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat has been associated with reduced antiepileptic drug levels and breakthrough seizures in case reports, probably due to reduced absorption. Data for eslicarbazepine specifically are lacking and the effect is theoretical.
How serious is the interaction between Eslicarbazepine and Orlistat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency when orlistat is started or stopped, and consider avoiding orlistat in patients with poorly controlled epilepsy.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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