Drug interactions
Eslicarbazepine + Pimavanserin
Severity: Moderate
Eslicarbazepine and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine may lower pimavanserin exposure and reduce its effect on psychosis symptoms. Strong inducers markedly reduce pimavanserin levels.
What this interaction means in plain words
Eslicarbazepine and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Pimavanserin belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases pimavanserin metabolism.
What to do
Monitor for loss of antipsychotic effect and consider a higher pimavanserin dose, or choose a non-inducing antiseizure drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Eslicarbazepine with Pimavanserin?
MediHelp rates the interaction as moderate. Eslicarbazepine and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine may lower pimavanserin exposure and reduce its effect on psychosis symptoms. Strong inducers markedly reduce pimavanserin levels.
How serious is the interaction between Eslicarbazepine and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antipsychotic effect and consider a higher pimavanserin dose, or choose a non-inducing antiseizure drug.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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