Drug interactions
Eslicarbazepine + Tadalafil
Severity: Moderate
Eslicarbazepine and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak to moderate CYP3A4 inducer and may reduce tadalafil levels. Reduced efficacy is possible.
What this interaction means in plain words
Eslicarbazepine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Tadalafil belongs to Genitourinary.
Why it happens
Eslicarbazepine induces CYP3A4, increasing tadalafil clearance.
What to do
Monitor response to tadalafil and increase the dose within labeled limits if erectile function is inadequate. In pulmonary hypertension, monitor functional status closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Tadalafil?
MediHelp rates the interaction as moderate. Eslicarbazepine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak to moderate CYP3A4 inducer and may reduce tadalafil levels. Reduced efficacy is possible.
How serious is the interaction between Eslicarbazepine and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response to tadalafil and increase the dose within labeled limits if erectile function is inadequate. In pulmonary hypertension, monitor functional status closely.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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