Drug interactions
Eslicarbazepine + Trabectedin
Severity: Moderate
Eslicarbazepine and Trabectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trabectedin is cleared mainly by CYP3A4, so induction may lower its exposure. This may reduce antitumor effect.
What this interaction means in plain words
Eslicarbazepine and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Trabectedin belongs to Oncology.
Why it happens
Eslicarbazepine induces CYP3A4, increasing trabectedin metabolism.
What to do
Prefer a non-inducing antiseizure drug. If combined, monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Trabectedin
Frequently asked questions
Can I take Eslicarbazepine with Trabectedin?
MediHelp rates the interaction as moderate. Eslicarbazepine and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trabectedin is cleared mainly by CYP3A4, so induction may lower its exposure. This may reduce antitumor effect.
How serious is the interaction between Eslicarbazepine and Trabectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiseizure drug. If combined, monitor tumor response.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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