Drug interactions
Eslicarbazepine + Zuranolone
Severity: Major
Eslicarbazepine and Zuranolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone is a CYP3A4 substrate and inducers reduce its exposure, possibly lessening antidepressant effect. Both drugs also cause CNS depression, so sedation may be additive.
What this interaction means in plain words
Eslicarbazepine and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eslicarbazepine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Eslicarbazepine induces CYP3A4 lowering zuranolone levels, and both agents have additive CNS depressant effects.
What to do
Monitor antidepressant response and sedation. Avoid strong inducers and counsel the patient not to drive.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Eslicarbazepine with Zuranolone?
MediHelp rates the interaction as major. Eslicarbazepine and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zuranolone is a CYP3A4 substrate and inducers reduce its exposure, possibly lessening antidepressant effect. Both drugs also cause CNS depression, so sedation may be additive.
How serious is the interaction between Eslicarbazepine and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and sedation. Avoid strong inducers and counsel the patient not to drive.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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