Drug interactions
Esmolol + Etrasimod
Severity: Moderate
Esmolol and Etrasimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can cause a transient fall in heart rate and delay AV conduction when started. Beta-blockers also slow heart rate and AV conduction, so the effect may be additive, especially if a beta-blocker is started after etrasimod.
What this interaction means in plain words
Esmolol and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive negative chronotropic and dromotropic effects from S1P receptor modulation and beta-1 adrenergic blockade.
What to do
Monitor heart rate and ECG when either drug is initiated while the other is on board. Seek cardiology input in patients with conduction disease or bradycardia risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Esmolol with Etrasimod?
MediHelp rates the interaction as moderate. Esmolol and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can cause a transient fall in heart rate and delay AV conduction when started. Beta-blockers also slow heart rate and AV conduction, so the effect may be additive, especially if a beta-blocker is started after etrasimod.
How serious is the interaction between Esmolol and Etrasimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG when either drug is initiated while the other is on board. Seek cardiology input in patients with conduction disease or bradycardia risk.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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