Drug interactions
Esmolol + Flurbiprofen
Severity: Minor
Esmolol and Flurbiprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can attenuate the antihypertensive effect of beta-blockers through prostaglandin inhibition and sodium and fluid retention. With short-acting intravenous esmolol, the practical relevance is limited and mainly relates to prolonged NSAID use.
What this interaction means in plain words
Esmolol and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esmolol belongs to Cardiovascular; Flurbiprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium retention opposes the blood-pressure-lowering effect.
What to do
Monitor blood pressure if flurbiprofen is used long term alongside beta-blocker therapy and adjust antihypertensive treatment if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Flurbiprofen?
MediHelp rates the interaction as minor. Esmolol and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can attenuate the antihypertensive effect of beta-blockers through prostaglandin inhibition and sodium and fluid retention. With short-acting intravenous esmolol, the practical relevance is limited and mainly relates to prolonged NSAID use.
How serious is the interaction between Esmolol and Flurbiprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if flurbiprofen is used long term alongside beta-blocker therapy and adjust antihypertensive treatment if needed.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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