Drug interactions
Esmolol + Fluticasone-salmeterol
Severity: Moderate
Esmolol and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol is a beta-blocker that can antagonize the bronchodilating action of salmeterol, and it may provoke bronchospasm in patients with asthma or COPD. Although esmolol is cardioselective, selectivity is lost at higher doses.
What this interaction means in plain words
Esmolol and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors.
What to do
Monitor respiratory status and bronchodilator response during esmolol infusion in patients with reactive airway disease. Use the lowest effective esmolol dose and have a short-acting bronchodilator available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Esmolol and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol is a beta-blocker that can antagonize the bronchodilating action of salmeterol, and it may provoke bronchospasm in patients with asthma or COPD. Although esmolol is cardioselective, selectivity is lost at higher doses.
How serious is the interaction between Esmolol and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status and bronchodilator response during esmolol infusion in patients with reactive airway disease. Use the lowest effective esmolol dose and have a short-acting bronchodilator available.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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