Drug interactions
Esmolol + Hydralazine
Severity: Minor
Esmolol and Hydralazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydralazine and esmolol lower blood pressure additively. Beta-blockers also blunt the reflex tachycardia caused by hydralazine, and the combination is often used deliberately.
What this interaction means in plain words
Esmolol and Hydralazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esmolol belongs to Cardiovascular; Hydralazine belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from arteriolar vasodilation and beta-blockade, with reflex tachycardia attenuated.
What to do
Monitor blood pressure and heart rate and titrate doses to the target.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Esmolol with Hydralazine?
MediHelp rates the interaction as minor. Esmolol and Hydralazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydralazine and esmolol lower blood pressure additively. Beta-blockers also blunt the reflex tachycardia caused by hydralazine, and the combination is often used deliberately.
How serious is the interaction between Esmolol and Hydralazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate doses to the target.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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