Drug interactions
Esmolol + Hydrochlorothiazide-valsartan
Severity: Minor
Esmolol and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol and the antihypertensive combination both lower blood pressure, so additive hypotension and bradycardia can occur. Beta-blockers can modestly raise potassium while the thiazide lowers it, so the net effect on potassium is uncertain.
What this interaction means in plain words
Esmolol and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esmolol belongs to Cardiovascular; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering by different mechanisms, with opposing minor effects on potassium handling.
What to do
Monitor blood pressure, heart rate and serum potassium during esmolol infusion. Adjust the esmolol infusion rate according to hemodynamic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Esmolol and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Esmolol and the antihypertensive combination both lower blood pressure, so additive hypotension and bradycardia can occur. Beta-blockers can modestly raise potassium while the thiazide lowers it, so the net effect on potassium is uncertain.
How serious is the interaction between Esmolol and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium during esmolol infusion. Adjust the esmolol infusion rate according to hemodynamic response.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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