Drug interactions
Esmolol + Insulin degludec-liraglutide
Severity: Moderate
Esmolol and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can alter glycemic response to insulin and may prolong hypoglycemia. They also blunt adrenergic warning symptoms such as tachycardia and tremor, so hypoglycemia may go unrecognized. Esmolol is short-acting, so the effect is brief.
What this interaction means in plain words
Esmolol and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Beta-blockade impairs glycogenolysis and gluconeogenic recovery from hypoglycemia and masks adrenergic symptoms.
What to do
Monitor blood glucose closely during esmolol infusion. Teach patients to rely on sweating and glucose readings rather than heart-rate symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Esmolol and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can alter glycemic response to insulin and may prolong hypoglycemia. They also blunt adrenergic warning symptoms such as tachycardia and tremor, so hypoglycemia may go unrecognized. Esmolol is short-acting, so the effect is brief.
How serious is the interaction between Esmolol and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during esmolol infusion. Teach patients to rely on sweating and glucose readings rather than heart-rate symptoms.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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