Drug interactions
Esmolol + Insulin degludec
Severity: Moderate
Esmolol and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can mask adrenergic warning signs of hypoglycemia such as tremor and tachycardia, and may delay glucose recovery. They can also alter glycemic control in either direction. Esmolol is short-acting and cardioselective, so the effect is generally limited.
What this interaction means in plain words
Esmolol and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Beta-blockade blunts adrenergic hypoglycemia symptoms and glycogenolysis while altering insulin secretion.
What to do
Monitor blood glucose more frequently and counsel patients that sweating may be the main sign of hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Esmolol with Insulin degludec?
MediHelp rates the interaction as moderate. Esmolol and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can mask adrenergic warning signs of hypoglycemia such as tremor and tachycardia, and may delay glucose recovery. They can also alter glycemic control in either direction. Esmolol is short-acting and cardioselective, so the effect is generally limited.
How serious is the interaction between Esmolol and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently and counsel patients that sweating may be the main sign of hypoglycemia.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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