Drug interactions
Esmolol + Mavacamten
Severity: Major
Esmolol and Mavacamten: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten lowers cardiac contractility and beta-blockers also reduce contractility and heart rate. Combined use may precipitate systolic dysfunction and heart failure, although beta-blockers are commonly used in obstructive hypertrophic cardiomyopathy under supervision.
What this interaction means in plain words
Esmolol and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Esmolol belongs to Cardiovascular; Mavacamten belongs to Cardiovascular.
Why it happens
Additive negative inotropic effects via myosin inhibition and beta-adrenergic blockade.
What to do
Monitor LVEF and clinical signs of heart failure with echocardiography as recommended in mavacamten labeling. Interrupt mavacamten if systolic function falls.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Esmolol with Mavacamten?
MediHelp rates the interaction as major. Esmolol and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten lowers cardiac contractility and beta-blockers also reduce contractility and heart rate. Combined use may precipitate systolic dysfunction and heart failure, although beta-blockers are commonly used in obstructive hypertrophic cardiomyopathy under supervision.
How serious is the interaction between Esmolol and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LVEF and clinical signs of heart failure with echocardiography as recommended in mavacamten labeling. Interrupt mavacamten if systolic function falls.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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