Drug interactions
Esmolol + Sacubitril-valsartan
Severity: Moderate
Esmolol and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol is a short-acting intravenous beta-blocker, and combined use with sacubitril-valsartan can cause additive hypotension, particularly in acutely ill patients. Beta-blockers may also slightly raise potassium.
What this interaction means in plain words
Esmolol and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from beta-blockade and angiotensin receptor blockade with neprilysin inhibition.
What to do
Monitor blood pressure continuously during esmolol infusion and potassium if therapy is prolonged. Adjust the esmolol infusion rate if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Esmolol and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol is a short-acting intravenous beta-blocker, and combined use with sacubitril-valsartan can cause additive hypotension, particularly in acutely ill patients. Beta-blockers may also slightly raise potassium.
How serious is the interaction between Esmolol and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during esmolol infusion and potassium if therapy is prolonged. Adjust the esmolol infusion rate if hypotension develops.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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