Drug interactions
Esmolol + Timolol
Severity: Moderate
Esmolol and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic timolol, or substantial absorption from ophthalmic use, adds non-selective beta-blockade to esmolol. This can cause additive bradycardia, hypotension and AV block.
What this interaction means in plain words
Esmolol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive beta-adrenergic receptor blockade.
What to do
Monitor heart rate, blood pressure and ECG during esmolol infusion in patients receiving timolol and titrate conservatively. Reduce or stop esmolol if significant bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Esmolol with Timolol?
MediHelp rates the interaction as moderate. Esmolol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic timolol, or substantial absorption from ophthalmic use, adds non-selective beta-blockade to esmolol. This can cause additive bradycardia, hypotension and AV block.
How serious is the interaction between Esmolol and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG during esmolol infusion in patients receiving timolol and titrate conservatively. Reduce or stop esmolol if significant bradycardia or hypotension occurs.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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