Drug interactions
Esmolol + Tolmetin
Severity: Minor
Esmolol and Tolmetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the blood pressure lowering effect of beta-blockers, mainly with sustained use. Esmolol is used short-term in acute settings, so the practical effect is likely small.
What this interaction means in plain words
Esmolol and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esmolol belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium and fluid retention oppose antihypertensive action.
What to do
Monitor blood pressure if tolmetin is used for more than a few days with beta-blocker therapy; adjust antihypertensive therapy if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Tolmetin?
MediHelp rates the interaction as minor. Esmolol and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can reduce the blood pressure lowering effect of beta-blockers, mainly with sustained use. Esmolol is used short-term in acute settings, so the practical effect is likely small.
How serious is the interaction between Esmolol and Tolmetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if tolmetin is used for more than a few days with beta-blocker therapy; adjust antihypertensive therapy if control is lost.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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