Drug interactions
Esomeprazole + Ferrous sulfate
Severity: Moderate
Esomeprazole and Ferrous sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iron salts need gastric acid for dissolution and absorption, so long-term PPI use can reduce iron uptake. This may delay recovery from iron deficiency.
What this interaction means in plain words
Esomeprazole and Ferrous sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esomeprazole belongs to Gastrointestinal Tract; Ferrous sulfate belongs to Miscellaneous.
Why it happens
Higher gastric pH reduces the solubility of ferric iron and the absorption of iron salts.
What to do
Monitor hemoglobin and ferritin, and consider a higher iron dose or IV iron if the response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Ferrous sulfate
Frequently asked questions
Can I take Esomeprazole with Ferrous sulfate?
MediHelp rates the interaction as moderate. Esomeprazole and Ferrous sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iron salts need gastric acid for dissolution and absorption, so long-term PPI use can reduce iron uptake. This may delay recovery from iron deficiency.
How serious is the interaction between Esomeprazole and Ferrous sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and ferritin, and consider a higher iron dose or IV iron if the response is poor.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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