Drug interactions
Esomeprazole + Flurazepam
Severity: Minor
Esomeprazole and Flurazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esomeprazole may raise levels of flurazepam's long-acting active metabolite, increasing sedation and psychomotor impairment. The effect is likely modest.
What this interaction means in plain words
Esomeprazole and Flurazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Esomeprazole inhibits CYP2C19-mediated metabolism of flurazepam.
What to do
Monitor for daytime sedation and reduce the flurazepam dose if needed, particularly in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Frequently asked questions
Can I take Esomeprazole with Flurazepam?
MediHelp rates the interaction as minor. Esomeprazole and Flurazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Esomeprazole may raise levels of flurazepam's long-acting active metabolite, increasing sedation and psychomotor impairment. The effect is likely modest.
How serious is the interaction between Esomeprazole and Flurazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for daytime sedation and reduce the flurazepam dose if needed, particularly in older patients.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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