Drug interactions
Esomeprazole + Infigratinib
Severity: Major
Esomeprazole and Infigratinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib absorption falls at higher gastric pH, so esomeprazole may lower its exposure and reduce its anticancer effect.
What this interaction means in plain words
Esomeprazole and Infigratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Higher gastric pH reduces the pH-dependent solubility and absorption of infigratinib.
What to do
Avoid PPIs with infigratinib. If acid suppression is needed, use a locally acting antacid, taking infigratinib 2 hours before or 2 hours after it.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Frequently asked questions
Can I take Esomeprazole with Infigratinib?
MediHelp rates the interaction as major. Esomeprazole and Infigratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Infigratinib absorption falls at higher gastric pH, so esomeprazole may lower its exposure and reduce its anticancer effect.
How serious is the interaction between Esomeprazole and Infigratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with infigratinib. If acid suppression is needed, use a locally acting antacid, taking infigratinib 2 hours before or 2 hours after it.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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