Drug interactions
Esomeprazole + Iron dextran complex
Severity: Minor
Esomeprazole and Iron dextran complex: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esomeprazole raises gastric pH, which can impair the dissolution and absorption of oral iron salts and iron complexes. Long-term acid suppression may blunt the response to oral iron and contribute to persistent iron deficiency. Parenteral iron dextran is not affected.
What this interaction means in plain words
Esomeprazole and Iron dextran complex have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Reduced gastric acidity decreases solubilization and reduction of ferric iron, lowering oral iron absorption.
What to do
Monitor hemoglobin and ferritin in patients on long-term PPI and oral iron, and consider a higher iron dose or switching to intravenous iron if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Frequently asked questions
Can I take Esomeprazole with Iron dextran complex?
MediHelp rates the interaction as minor. Esomeprazole and Iron dextran complex have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Esomeprazole raises gastric pH, which can impair the dissolution and absorption of oral iron salts and iron complexes. Long-term acid suppression may blunt the response to oral iron and contribute to persistent iron deficiency. Parenteral iron dextran is not affected.
How serious is the interaction between Esomeprazole and Iron dextran complex?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and ferritin in patients on long-term PPI and oral iron, and consider a higher iron dose or switching to intravenous iron if response is inadequate.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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