Drug interactions
Esomeprazole + Isoniazid
Severity: Minor
Esomeprazole and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid inhibits CYP2C19 and may modestly raise esomeprazole concentrations. The clinical consequence is generally small because esomeprazole has a wide safety margin.
What this interaction means in plain words
Esomeprazole and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esomeprazole belongs to Gastrointestinal Tract; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP2C19, reducing esomeprazole clearance.
What to do
No dose adjustment is normally required. Be aware of increased esomeprazole effects during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Isoniazid
Frequently asked questions
Can I take Esomeprazole with Isoniazid?
MediHelp rates the interaction as minor. Esomeprazole and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid inhibits CYP2C19 and may modestly raise esomeprazole concentrations. The clinical consequence is generally small because esomeprazole has a wide safety margin.
How serious is the interaction between Esomeprazole and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is normally required. Be aware of increased esomeprazole effects during prolonged co-therapy.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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