Drug interactions
Esomeprazole + Liotrix
Severity: Minor
Esomeprazole and Liotrix: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid suppression by esomeprazole may reduce absorption of the oral T3/T4 combination in liotrix. Evidence is mostly extrapolated from levothyroxine and is inconsistent.
What this interaction means in plain words
Esomeprazole and Liotrix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Raised gastric pH may reduce dissolution and absorption of oral thyroid hormones.
What to do
Monitor TSH and thyroid hormone levels after starting, stopping or changing the dose of esomeprazole, and adjust liotrix as required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Frequently asked questions
Can I take Esomeprazole with Liotrix?
MediHelp rates the interaction as minor. Esomeprazole and Liotrix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Acid suppression by esomeprazole may reduce absorption of the oral T3/T4 combination in liotrix. Evidence is mostly extrapolated from levothyroxine and is inconsistent.
How serious is the interaction between Esomeprazole and Liotrix?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor TSH and thyroid hormone levels after starting, stopping or changing the dose of esomeprazole, and adjust liotrix as required.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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