Drug interactions
Esomeprazole + Lumacaftor / ivacaftor
Severity: Moderate
Esomeprazole and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor induces CYP enzymes including CYP2C19 and CYP3A4 on net, which can lower exposure to esomeprazole. Reduced PPI exposure may weaken acid suppression.
What this interaction means in plain words
Esomeprazole and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor-mediated induction of CYP2C19 and CYP3A4 increases esomeprazole metabolism.
What to do
Monitor for loss of symptom control and increase the esomeprazole dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Frequently asked questions
Can I take Esomeprazole with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Esomeprazole and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor induces CYP enzymes including CYP2C19 and CYP3A4 on net, which can lower exposure to esomeprazole. Reduced PPI exposure may weaken acid suppression.
How serious is the interaction between Esomeprazole and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and increase the esomeprazole dose if needed.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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