Drug interactions
Esomeprazole + Mycophenolate
Severity: Moderate
Esomeprazole and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
PPIs can reduce the absorption of mycophenolic acid from mycophenolate mofetil, lowering exposure to the active drug. This could theoretically raise the risk of rejection, although the clinical significance is uncertain and enteric-coated mycophenolate sodium is less affected.
What this interaction means in plain words
Esomeprazole and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased gastric pH reduces dissolution and absorption of mycophenolate mofetil.
What to do
Monitor for graft function and rejection signs, and consider mycophenolic acid exposure monitoring. Consider enteric-coated mycophenolate sodium or an H2 blocker alternative if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Frequently asked questions
Can I take Esomeprazole with Mycophenolate?
MediHelp rates the interaction as moderate. Esomeprazole and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. PPIs can reduce the absorption of mycophenolic acid from mycophenolate mofetil, lowering exposure to the active drug. This could theoretically raise the risk of rejection, although the clinical significance is uncertain and enteric-coated mycophenolate sodium is less affected.
How serious is the interaction between Esomeprazole and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for graft function and rejection signs, and consider mycophenolic acid exposure monitoring. Consider enteric-coated mycophenolate sodium or an H2 blocker alternative if feasible.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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