Drug interactions
Esomeprazole + Pentobarbital
Severity: Minor
Esomeprazole and Pentobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic CYP enzymes including CYP2C19 and CYP3A4. Chronic pentobarbital use may lower esomeprazole concentrations and reduce its acid-suppressing effect.
What this interaction means in plain words
Esomeprazole and Pentobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pentobarbital induces CYP2C19 and CYP3A4, accelerating esomeprazole clearance.
What to do
Monitor symptom control and raise the esomeprazole dose if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Frequently asked questions
Can I take Esomeprazole with Pentobarbital?
MediHelp rates the interaction as minor. Esomeprazole and Pentobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic CYP enzymes including CYP2C19 and CYP3A4. Chronic pentobarbital use may lower esomeprazole concentrations and reduce its acid-suppressing effect.
How serious is the interaction between Esomeprazole and Pentobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and raise the esomeprazole dose if response is inadequate.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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