Drug interactions
Esomeprazole + Polysaccharide iron
Severity: Minor
Esomeprazole and Polysaccharide iron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reduced gastric acid from esomeprazole can lower absorption of oral iron preparations. Polysaccharide iron complex may be less dependent on acid than iron salts, but prolonged PPI therapy can still contribute to a suboptimal iron response.
What this interaction means in plain words
Esomeprazole and Polysaccharide iron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Higher gastric pH reduces iron solubilization and absorption.
What to do
Check hemoglobin and ferritin during long-term co-therapy and consider intravenous iron if oral repletion is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Frequently asked questions
Can I take Esomeprazole with Polysaccharide iron?
MediHelp rates the interaction as minor. Esomeprazole and Polysaccharide iron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reduced gastric acid from esomeprazole can lower absorption of oral iron preparations. Polysaccharide iron complex may be less dependent on acid than iron salts, but prolonged PPI therapy can still contribute to a suboptimal iron response.
How serious is the interaction between Esomeprazole and Polysaccharide iron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check hemoglobin and ferritin during long-term co-therapy and consider intravenous iron if oral repletion is inadequate.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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