Drug interactions
Esomeprazole + Ponatinib
Severity: Minor
Esomeprazole and Ponatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib has pH-dependent solubility, so acid suppression could theoretically reduce its absorption. In clinical studies, the PPI lansoprazole produced only a small reduction in ponatinib exposure that was not considered clinically significant.
What this interaction means in plain words
Esomeprazole and Ponatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esomeprazole belongs to Gastrointestinal Tract; Ponatinib belongs to Oncology.
Why it happens
Higher gastric pH reduces ponatinib solubility, but the effect on exposure is small.
What to do
No routine dose change is needed; monitor response to ponatinib in patients on long-term acid suppression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Ponatinib
Frequently asked questions
Can I take Esomeprazole with Ponatinib?
MediHelp rates the interaction as minor. Esomeprazole and Ponatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ponatinib has pH-dependent solubility, so acid suppression could theoretically reduce its absorption. In clinical studies, the PPI lansoprazole produced only a small reduction in ponatinib exposure that was not considered clinically significant.
How serious is the interaction between Esomeprazole and Ponatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor response to ponatinib in patients on long-term acid suppression.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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