Drug interactions
Estazolam + Mirtazapine
Severity: Moderate
Estazolam and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estazolam is a hypnotic benzodiazepine and mirtazapine is also strongly sedating. Combined use increases daytime drowsiness, psychomotor impairment, falls and respiratory depression risk, especially in older adults.
What this interaction means in plain words
Estazolam and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation by estazolam and histamine H1 antagonism by mirtazapine.
What to do
Use the lowest effective doses and consider reducing the estazolam dose. Monitor for oversedation and falls, and advise against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Estazolam with Mirtazapine?
MediHelp rates the interaction as moderate. Estazolam and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estazolam is a hypnotic benzodiazepine and mirtazapine is also strongly sedating. Combined use increases daytime drowsiness, psychomotor impairment, falls and respiratory depression risk, especially in older adults.
How serious is the interaction between Estazolam and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and consider reducing the estazolam dose. Monitor for oversedation and falls, and advise against driving.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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