Drug interactions
Estazolam + Trazodone
Severity: Moderate
Estazolam and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estazolam is a benzodiazepine hypnotic, and combining it with trazodone increases the risk of next-day sedation, dizziness, confusion and impaired psychomotor performance. Older adults are at greater risk of falls.
What this interaction means in plain words
Estazolam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation plus sedating antidepressant effects.
What to do
Use the lowest effective doses for the shortest time and monitor for oversedation and falls. Avoid alcohol and consider dose reduction in the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Estazolam with Trazodone?
MediHelp rates the interaction as moderate. Estazolam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estazolam is a benzodiazepine hypnotic, and combining it with trazodone increases the risk of next-day sedation, dizziness, confusion and impaired psychomotor performance. Older adults are at greater risk of falls.
How serious is the interaction between Estazolam and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and monitor for oversedation and falls. Avoid alcohol and consider dose reduction in the elderly.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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