Drug interactions
Estradiol + Glecaprevir / pibrentasvir
Severity: Minor
Estradiol and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit intestinal P-glycoprotein and may modestly raise exposure to estradiol. Clinically, this is expected to cause little change, though estrogenic adverse effects could occur.
What this interaction means in plain words
Estradiol and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of P-glycoprotein efflux (and possibly BCRP) increases estradiol absorption.
What to do
No routine dose change is needed; watch for estrogenic effects such as breast tenderness or nausea and reduce the estradiol dose if they occur. Note that ethinylestradiol-containing products are a separate concern with this HCV regimen because of ALT elevations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Estradiol and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit intestinal P-glycoprotein and may modestly raise exposure to estradiol. Clinically, this is expected to cause little change, though estrogenic adverse effects could occur.
How serious is the interaction between Estradiol and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for estrogenic effects such as breast tenderness or nausea and reduce the estradiol dose if they occur. Note that ethinylestradiol-containing products are a separate concern with this HCV regimen because of ALT elevations.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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